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María del Carmen Félix is a Mexican actress best known for her role of Leticia Cabral in the Telemundo's series "La Doña" (2016–1017).
Her first notable roles was in "Drunk History" Mexican version of the American series of the same name, In the series she played her great-aunt María Félix.
Her other notable TV roles include "Su nombre era Dolores, la Jenn que yo conocí", biographical series about the Mexican singer Jenni Rivera, and "Enemigo íntimo".
Kumar and Mr. Jones
Kumar and Mr. Jones is a Canadian short drama film, directed by Sugith Varughese and released in 1991.
The film centres on the relationship between Mr. Jones (John Gilbert), a bedridden older man, and Kumar (Ivan Smith), his Indo-Canadian caretaker whose power in the relationship is threatened when Mr. Jones begins responding favourably to treatment by Melissa (Michelle Duquet), a new physical therapist.
The film was made while Varughese was a student at the Canadian Film Centre.
The film received a Genie Award nomination for Best Live Action Short Drama at the 13th Genie Awards in 1992.
(Let's Get Together) One Last Time
"(Let's Get Together) One Last Time" is a song written by Billy Sherrill and George Richey.
It was originally recorded by American country artist Tammy Wynette and released as a single in 1977.
"Let's Get Together" was first recorded in December 1976 at the Columbia Recording Studio in Nashville, Tennessee.
Additional tracks were recorded during this session, which would ultimately become part of Wynette's studio album "Let's Get Together".
The session was produced by Billy Sherrill and the song was issued as a single in January 1977.
The song reached number 6 on the "Billboard" Hot Country Singles chart.
It released on her studio album "Let's Get Together".
Tettigometridae
The Tettigometridae are a family of Fulgoromorpha (planthoppers), with a species distribution from: Europe, Africa, Asia through to west Malesia.
"Fulgoromorpha Lists On the Web" includes the following:
Auth.
: Baker, 1924 (West Africa, Indo-China, Malesia)
Auth.
: Bourgoin, 2018
Auth.
: Ghauri, 1964 (central Africa)
Auth.
: Germar, 1821
A Midsummer's Nightmare (film)
A Midsummer's Nightmare is a 2017 psychological thriller film directed by Gary Fleder.
It is a modern adaptation of the play "A Midsummer Night's Dream" by William Shakespeare.
Four young lovers go into the woods pursue their romantic desires but find their fantasies and secrets being used against them.
The film was produced as a pilot for a planned hour-long anthology series but the pilot was not picked up as a series.
Filming took place in Vancouver and elsewhere in British Columbia, Canada from October 31 to November 18, 2016.
Liz Gateley, Executive Vice President and Head of Programming for Lifetime, stated that the intent was to develop "content that redefines what it means to be a Lifetime show."
The production received some media attention for booking Courtney Love in a role.
The pilot was originally scheduled to premiere on July 28, 2017 but was then moved to July 14 and then again to July 31, when it ultimately aired.
Reviewer Duane of the website Shakespeare Geek gave the film a negative review, doubting the existence of "any Shakespeare of note" in it.
One of a Kind (Tammy Wynette song)
"One of a Kind" is a song written by Billy Sherrill and Stephen Allen Davis.
It was originally recorded by American country artist Tammy Wynette and released as a single in 1977.
"One of a Kind" was first recorded in December 1976 at the Columbia Recording Studio in Nashville, Tennessee.
Additional tracks were recorded during this session, which would ultimately become part of Wynette's studio album "One of a Kind".
The session was produced by Billy Sherrill and the song was issued as a single in August 1977.
The song reached number 6 on the "Billboard" Hot Country Singles chart.
It released on her studio album "One of a Kind".
2020 ITF Men's World Tennis Tour (January–March)
The 2020 ITF Men's World Tennis Tour is the 2020 edition of the second tier tour for men's professional tennis.
It is organised by the International Tennis Federation and is a tier below the ATP Tour.
The ITF Men's World Tennis Tour includes tournaments with prize money ranging from $15,000 to $25,000.
Enchantress (1828 ship)
Enchantress was launched in 1828 at Bristol as a West Indiaman.
She then traded with India as an East Indiaman, sailing under a license issued by the British East India Company (EIC).
She next transported convicts to Van Diemen's Land.
She was wrecked in February 1837 at Bermuda.
"Enchantress" first appeared in "Lloyd's Register" ("LR") in 1829 with W.Drew, master and owner, and trade Bristol-Saint Vincent.
In 1813 the EIC had lost its monopoly on the trade between India and Britain.
British ships were then free to sail to India or the Indian Ocean under a license from the EIC.
On 9 April 1830 Captain Drew sailed for Calcutta under a license from the EIC.
On 13 April 1833 Captain Thomas Canney sailed from Portsmouth, bound for Van Diemen's Land with a cargo of convicts.
"Enchantress" arrived at Hobart town on 31 July.
She had embarked 200 male convicts and landed 199, one having died on the voyage.
"Enchantress" struck a reef on 5 February 1837 off Bermuda and sank.
All on board were rescued.
She was on a voyage from Liverpool, to New York.
Her master was Captain George Donaldson, and she was carrying 66 or 74 Irish emigrants, two of whom died on the voyage.
Her destination was New York but bad weather and damage to the vessel led Donaldson to make for Bermuda.
Citations
References
Hypochthonella
Hypochthonella is a monotypic genus of Fulgoromorpha (planthoppers), with the single species, Hypochthonella caeca discovered from Zimbabwe.
This species is the only known representative of the monotypic family Hypochthonellidae .
Shirakumo Shrine
Shirakumo Shrine is a Shinto shrine in Kyoto Gyoen National Garden, in Kyoto, Japan.
Sérgio Santos (footballer, born 1998)
Sérgio Assis Capitango Fernando Santos (born 2 October 1998) is a Portuguese professional footballer who plays as a forward for Portimonense.
Santos made his professional debut with Portimonense in a 2-1 Taça da Liga win over Gil Vicente F.C.
on 25 September 2019.
H3K23ac
H3K23ac is an epigenetic modification to the DNA packaging protein Histone H3.
It is a mark that indicates the acetylation at the 23rd lysine residue of the histone H3 protein.
H3K23ac is not well studied but is correlated to TRIM24 in breast cancer.
Proteins are typically acetylated on lysine residues and this reaction relies on acetyl-coenzyme A as the acetyl group donor.
In histone acetylation and deacetylation, histone proteins are acetylated and deacetylated on lysine residues in the N-terminal tail as part of gene regulation.
Typically, these reactions are catalyzed by enzymes with "histone acetyltransferase" (HAT) or "histone deacetylase" (HDAC) activity, although HATs and HDACs can modify the acetylation status of non-histone proteins as well.
The regulation of transcription factors, effector proteins, molecular chaperones, and cytoskeletal proteins by acetylation and deacetylation is a significant post-translational regulatory mechanism These regulatory mechanisms are analogous to phosphorylation and dephosphorylation by the action of kinases and phosphatases.
Not only can the acetylation state of a protein modify its activity but there has been recent suggestion that this post-translational modification may also crosstalk with phosphorylation, methylation, ubiquitination, sumoylation, and others for dynamic control of cellular signaling.
In the field of epigenetics, histone acetylation (and deacetylation) have been shown to be important mechanisms in the regulation of gene transcription.
Histones, however, are not the only proteins regulated by posttranslational acetylation.
H3K23ac indicates acetylation of lysine 23 on histone H3 protein subunit:
The genomic DNA of eukaryotic cells is wrapped around special protein molecules known as Histones.
The complexes formed by the looping of the DNA are known as chromatin.
The basic structural unit of chromatin is the nucleosome: this consists of the core octamer of histones (H2A, H2B, H3 and H4) as well as a linker histone and about 180 base pairs of DNA.
These core histones are rich in lysine and arginine residues.
The carboxyl (C) terminal end of these histones contribute to histone-histone interactions, as well as histone-DNA interactions.
The amino (N) terminal charged tails are the site of the post-translational modifications, such as the one seen in H3K36me3.
The post-translational modification of histone tails by either histone modifying complexes or chromatin remodelling complexes are interpreted by the cell and lead to complex, combinatorial transcriptional output.
It is thought that a Histone code dictates the expression of genes by a complex interaction between the histones in a particular region.
The current understanding and interpretation of histones comes from two large scale projects: ENCODE and the Epigenomic roadmap.
The purpose of the epigenomic study was to investigate epigenetic changes across the entire genome.
This led to chromatin states which define genomic regions by grouping the interactions of different proteins and/or histone modifications together.