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María del Carmen Félix is a Mexican actress best known for her role of Leticia Cabral in the Telemundo's series "La Doña" (2016–1017).
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Her first notable roles was in "Drunk History" Mexican version of the American series of the same name, In the series she played her great-aunt María Félix.
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Her other notable TV roles include "Su nombre era Dolores, la Jenn que yo conocí", biographical series about the Mexican singer Jenni Rivera, and "Enemigo íntimo".
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Kumar and Mr. Jones
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Kumar and Mr. Jones is a Canadian short drama film, directed by Sugith Varughese and released in 1991.
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The film centres on the relationship between Mr. Jones (John Gilbert), a bedridden older man, and Kumar (Ivan Smith), his Indo-Canadian caretaker whose power in the relationship is threatened when Mr. Jones begins responding favourably to treatment by Melissa (Michelle Duquet), a new physical therapist.
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The film was made while Varughese was a student at the Canadian Film Centre.
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The film received a Genie Award nomination for Best Live Action Short Drama at the 13th Genie Awards in 1992.
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(Let's Get Together) One Last Time
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"(Let's Get Together) One Last Time" is a song written by Billy Sherrill and George Richey.
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It was originally recorded by American country artist Tammy Wynette and released as a single in 1977.
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"Let's Get Together" was first recorded in December 1976 at the Columbia Recording Studio in Nashville, Tennessee.
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Additional tracks were recorded during this session, which would ultimately become part of Wynette's studio album "Let's Get Together".
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The session was produced by Billy Sherrill and the song was issued as a single in January 1977.
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The song reached number 6 on the "Billboard" Hot Country Singles chart.
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It released on her studio album "Let's Get Together".
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Tettigometridae
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The Tettigometridae are a family of Fulgoromorpha (planthoppers), with a species distribution from: Europe, Africa, Asia through to west Malesia.
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"Fulgoromorpha Lists On the Web" includes the following:
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Auth.
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: Baker, 1924 (West Africa, Indo-China, Malesia)
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Auth.
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: Bourgoin, 2018
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Auth.
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: Ghauri, 1964 (central Africa)
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Auth.
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: Germar, 1821
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A Midsummer's Nightmare (film)
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A Midsummer's Nightmare is a 2017 psychological thriller film directed by Gary Fleder.
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It is a modern adaptation of the play "A Midsummer Night's Dream" by William Shakespeare.
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Four young lovers go into the woods pursue their romantic desires but find their fantasies and secrets being used against them.
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The film was produced as a pilot for a planned hour-long anthology series but the pilot was not picked up as a series.
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Filming took place in Vancouver and elsewhere in British Columbia, Canada from October 31 to November 18, 2016.
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Liz Gateley, Executive Vice President and Head of Programming for Lifetime, stated that the intent was to develop "content that redefines what it means to be a Lifetime show."
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The production received some media attention for booking Courtney Love in a role.
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The pilot was originally scheduled to premiere on July 28, 2017 but was then moved to July 14 and then again to July 31, when it ultimately aired.
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Reviewer Duane of the website Shakespeare Geek gave the film a negative review, doubting the existence of "any Shakespeare of note" in it.
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One of a Kind (Tammy Wynette song)
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"One of a Kind" is a song written by Billy Sherrill and Stephen Allen Davis.
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It was originally recorded by American country artist Tammy Wynette and released as a single in 1977.
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"One of a Kind" was first recorded in December 1976 at the Columbia Recording Studio in Nashville, Tennessee.
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Additional tracks were recorded during this session, which would ultimately become part of Wynette's studio album "One of a Kind".
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The session was produced by Billy Sherrill and the song was issued as a single in August 1977.
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The song reached number 6 on the "Billboard" Hot Country Singles chart.
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It released on her studio album "One of a Kind".
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2020 ITF Men's World Tennis Tour (January–March)
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The 2020 ITF Men's World Tennis Tour is the 2020 edition of the second tier tour for men's professional tennis.
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It is organised by the International Tennis Federation and is a tier below the ATP Tour.
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The ITF Men's World Tennis Tour includes tournaments with prize money ranging from $15,000 to $25,000.
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Enchantress (1828 ship)
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Enchantress was launched in 1828 at Bristol as a West Indiaman.
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She then traded with India as an East Indiaman, sailing under a license issued by the British East India Company (EIC).
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She next transported convicts to Van Diemen's Land.
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She was wrecked in February 1837 at Bermuda.
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"Enchantress" first appeared in "Lloyd's Register" ("LR") in 1829 with W.Drew, master and owner, and trade Bristol-Saint Vincent.
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In 1813 the EIC had lost its monopoly on the trade between India and Britain.
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British ships were then free to sail to India or the Indian Ocean under a license from the EIC.
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On 9 April 1830 Captain Drew sailed for Calcutta under a license from the EIC.
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On 13 April 1833 Captain Thomas Canney sailed from Portsmouth, bound for Van Diemen's Land with a cargo of convicts.
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"Enchantress" arrived at Hobart town on 31 July.
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She had embarked 200 male convicts and landed 199, one having died on the voyage.
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"Enchantress" struck a reef on 5 February 1837 off Bermuda and sank.
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All on board were rescued.
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She was on a voyage from Liverpool, to New York.
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Her master was Captain George Donaldson, and she was carrying 66 or 74 Irish emigrants, two of whom died on the voyage.
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Her destination was New York but bad weather and damage to the vessel led Donaldson to make for Bermuda.
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Citations
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References
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Hypochthonella
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Hypochthonella is a monotypic genus of Fulgoromorpha (planthoppers), with the single species, Hypochthonella caeca discovered from Zimbabwe.
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This species is the only known representative of the monotypic family Hypochthonellidae .
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Shirakumo Shrine
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Shirakumo Shrine is a Shinto shrine in Kyoto Gyoen National Garden, in Kyoto, Japan.
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Sérgio Santos (footballer, born 1998)
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Sérgio Assis Capitango Fernando Santos (born 2 October 1998) is a Portuguese professional footballer who plays as a forward for Portimonense.
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Santos made his professional debut with Portimonense in a 2-1 Taça da Liga win over Gil Vicente F.C.
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on 25 September 2019.
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H3K23ac
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H3K23ac is an epigenetic modification to the DNA packaging protein Histone H3.
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It is a mark that indicates the acetylation at the 23rd lysine residue of the histone H3 protein.
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H3K23ac is not well studied but is correlated to TRIM24 in breast cancer.
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Proteins are typically acetylated on lysine residues and this reaction relies on acetyl-coenzyme A as the acetyl group donor.
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In histone acetylation and deacetylation, histone proteins are acetylated and deacetylated on lysine residues in the N-terminal tail as part of gene regulation.
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Typically, these reactions are catalyzed by enzymes with "histone acetyltransferase" (HAT) or "histone deacetylase" (HDAC) activity, although HATs and HDACs can modify the acetylation status of non-histone proteins as well.
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The regulation of transcription factors, effector proteins, molecular chaperones, and cytoskeletal proteins by acetylation and deacetylation is a significant post-translational regulatory mechanism These regulatory mechanisms are analogous to phosphorylation and dephosphorylation by the action of kinases and phosphatases.
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Not only can the acetylation state of a protein modify its activity but there has been recent suggestion that this post-translational modification may also crosstalk with phosphorylation, methylation, ubiquitination, sumoylation, and others for dynamic control of cellular signaling.
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In the field of epigenetics, histone acetylation (and deacetylation) have been shown to be important mechanisms in the regulation of gene transcription.
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Histones, however, are not the only proteins regulated by posttranslational acetylation.
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H3K23ac indicates acetylation of lysine 23 on histone H3 protein subunit:
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The genomic DNA of eukaryotic cells is wrapped around special protein molecules known as Histones.
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The complexes formed by the looping of the DNA are known as chromatin.
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The basic structural unit of chromatin is the nucleosome: this consists of the core octamer of histones (H2A, H2B, H3 and H4) as well as a linker histone and about 180 base pairs of DNA.
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These core histones are rich in lysine and arginine residues.
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The carboxyl (C) terminal end of these histones contribute to histone-histone interactions, as well as histone-DNA interactions.
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The amino (N) terminal charged tails are the site of the post-translational modifications, such as the one seen in H3K36me3.
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The post-translational modification of histone tails by either histone modifying complexes or chromatin remodelling complexes are interpreted by the cell and lead to complex, combinatorial transcriptional output.
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It is thought that a Histone code dictates the expression of genes by a complex interaction between the histones in a particular region.
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The current understanding and interpretation of histones comes from two large scale projects: ENCODE and the Epigenomic roadmap.
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The purpose of the epigenomic study was to investigate epigenetic changes across the entire genome.
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This led to chromatin states which define genomic regions by grouping the interactions of different proteins and/or histone modifications together.
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