Datasets:
MicPie
/
unpredictable_cluster18

Dataset card Data Studio Files Community
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9a4fe989_Kingdoms_Of_Life__0
[1] maura [2] borealis [0]
Species
[ [ "K", "i", "n", "g", "d", "o", "m" ], [ "P", "h", "y", "l", "u", "m" ], [ "C", "l", "a", "s", "s" ], [ "O", "r", "d", "e", "r" ], [ "F", "a", "m", "i", "l", "y" ], [ "G", "e", "n", "u", "s" ], [ "S", "p", "e", "c", "i", "e", "s" ] ]
Kingdoms Of Life
0
http://waynesword.palomar.edu/trfeb98.htm
21/1438043062635.98_20150728002422-00105-ip-10-236-191-2_256024231_17.json
80a6ff2c_WPSA___food_safety__0
[1] CCP No. [2] Hazard (Source) [3] Preventive Measure [4] Limits [5] Monitoring [6] Corrective Action [7] Doc. Ref [0]
Step
[]
WPSA - food safety
0
http://www.wpsa-foodsafety.com/index.php?item=167
21/1438043062635.98_20150728002422-00337-ip-10-236-191-2_846080767_0.json
80a6ff2c_WPSA___food_safety__0
[1] CCP 1 [2] Disease carriers [3] Poultry from certified origin [5] Health check Pathogen carrier status [6] Vaccination or medical treatment quarantain [0]
Chicks history, Pre-lay
[]
WPSA - food safety
0
http://www.wpsa-foodsafety.com/index.php?item=167
21/1438043062635.98_20150728002422-00337-ip-10-236-191-2_846080767_0.json
80a6ff2c_WPSA___food_safety__0
[1] CCP 2 [2] Product contamination due to pathogens and medication misuse [3] Feed from certified origin Feed produced under certified conditions [4] cfu numbers Pathogens (Salmonella) E.coli [5] statistics of analysis. Q-reports or certificates. additional sampling [6] quarantain or refusal [0]
Feed and storage
[]
WPSA - food safety
0
http://www.wpsa-foodsafety.com/index.php?item=167
21/1438043062635.98_20150728002422-00337-ip-10-236-191-2_846080767_0.json
80a6ff2c_WPSA___food_safety__0
[2] public source or local well [3] local well should be monitored regularly [4] comparable to public source quality [5] wells should be monitored once or twice a year [6] Expert advice [0]
Water and storage
[]
WPSA - food safety
0
http://www.wpsa-foodsafety.com/index.php?item=167
21/1438043062635.98_20150728002422-00337-ip-10-236-191-2_846080767_0.json
80a6ff2c_WPSA___food_safety__0
[2] pests animals (mice, insects) Hygiene location Moisture Temperture regulation [3] control regular C&D Visual and mechanical checks [5] frequent monitoring of systems: catching devices; tempertature; humidity [0]
Packaging and storage
[]
WPSA - food safety
0
http://www.wpsa-foodsafety.com/index.php?item=167
21/1438043062635.98_20150728002422-00337-ip-10-236-191-2_846080767_0.json
80a6ff2c_WPSA___food_safety__0
[2] hygiene of transport systems, both mechanically and hygienically [3] no mechanincal or hygienic defects [5] visual checks, constant monitoring of egg damage or pollution. [6] repairs [0]
Egg collection and removal from production house
[]
WPSA - food safety
0
http://www.wpsa-foodsafety.com/index.php?item=167
21/1438043062635.98_20150728002422-00337-ip-10-236-191-2_846080767_0.json
80a6ff2c_WPSA___food_safety__0
[2] hygiene of systems, both mechanically and hygienically [3] no mechanincal or hygienic defects [5] visual checks, constant monitoring of egg damage or pollution. [6] repairs [0]
Egg handling and delivery to packing centre
[]
WPSA - food safety
0
http://www.wpsa-foodsafety.com/index.php?item=167
21/1438043062635.98_20150728002422-00337-ip-10-236-191-2_846080767_0.json
82a9d63b_ular_Manipulation___KurzweilAI__Molecular_example_s_
[Technology] Struts, beams, casings [Function] Transmit force, hold positions [Molecular example(s)]
Microtubules, cellulose, mineral structures
[]
ENGINES of CREATION 2.0 | Molecular Engineering: An Approach to the Development of General Capabilities for Molecular Manipulation | KurzweilAI
Molecular example(s)
http://www.kurzweilai.net/engines-of-creation-2-molecular-engineering-approach
21/1438042988840.31_20150728002308-00039-ip-10-236-191-2_549821761_0.json
82a9d63b_ular_Manipulation___KurzweilAI__Molecular_example_s_
[Technology] Cables [Function] Transmit tension [Molecular example(s)]
Collagen
[]
ENGINES of CREATION 2.0 | Molecular Engineering: An Approach to the Development of General Capabilities for Molecular Manipulation | KurzweilAI
Molecular example(s)
http://www.kurzweilai.net/engines-of-creation-2-molecular-engineering-approach
21/1438042988840.31_20150728002308-00039-ip-10-236-191-2_549821761_0.json
82a9d63b_ular_Manipulation___KurzweilAI__Molecular_example_s_
[Technology] Fasteners, glue [Function] Connect parts [Molecular example(s)]
Intermolecular forces
[]
ENGINES of CREATION 2.0 | Molecular Engineering: An Approach to the Development of General Capabilities for Molecular Manipulation | KurzweilAI
Molecular example(s)
http://www.kurzweilai.net/engines-of-creation-2-molecular-engineering-approach
21/1438042988840.31_20150728002308-00039-ip-10-236-191-2_549821761_0.json
82a9d63b_ular_Manipulation___KurzweilAI__Molecular_example_s_
[Technology] Solenoids, actuators [Function] Move things [Molecular example(s)]
Conformation-changing proteins, actin/myosin
[]
ENGINES of CREATION 2.0 | Molecular Engineering: An Approach to the Development of General Capabilities for Molecular Manipulation | KurzweilAI
Molecular example(s)
http://www.kurzweilai.net/engines-of-creation-2-molecular-engineering-approach
21/1438042988840.31_20150728002308-00039-ip-10-236-191-2_549821761_0.json
82a9d63b_ular_Manipulation___KurzweilAI__Molecular_example_s_
[Technology] Motors [Function] Turn shafts [Molecular example(s)]
Flagellar motor
[]
ENGINES of CREATION 2.0 | Molecular Engineering: An Approach to the Development of General Capabilities for Molecular Manipulation | KurzweilAI
Molecular example(s)
http://www.kurzweilai.net/engines-of-creation-2-molecular-engineering-approach
21/1438042988840.31_20150728002308-00039-ip-10-236-191-2_549821761_0.json
82a9d63b_ular_Manipulation___KurzweilAI__Molecular_example_s_
[Technology] Drive shafts [Function] Transmit torque [Molecular example(s)]
Bacterial flagella
[]
ENGINES of CREATION 2.0 | Molecular Engineering: An Approach to the Development of General Capabilities for Molecular Manipulation | KurzweilAI
Molecular example(s)
http://www.kurzweilai.net/engines-of-creation-2-molecular-engineering-approach
21/1438042988840.31_20150728002308-00039-ip-10-236-191-2_549821761_0.json
82a9d63b_ular_Manipulation___KurzweilAI__Molecular_example_s_
[Technology] Bearings [Function] Support moving parts [Molecular example(s)]
Sigma bonds
[]
ENGINES of CREATION 2.0 | Molecular Engineering: An Approach to the Development of General Capabilities for Molecular Manipulation | KurzweilAI
Molecular example(s)
http://www.kurzweilai.net/engines-of-creation-2-molecular-engineering-approach
21/1438042988840.31_20150728002308-00039-ip-10-236-191-2_549821761_0.json
82a9d63b_ular_Manipulation___KurzweilAI__Molecular_example_s_
[Technology] Containers [Function] Hold fluids [Molecular example(s)]
Vesicles
[]
ENGINES of CREATION 2.0 | Molecular Engineering: An Approach to the Development of General Capabilities for Molecular Manipulation | KurzweilAI
Molecular example(s)
http://www.kurzweilai.net/engines-of-creation-2-molecular-engineering-approach
21/1438042988840.31_20150728002308-00039-ip-10-236-191-2_549821761_0.json
82a9d63b_ular_Manipulation___KurzweilAI__Molecular_example_s_
[Technology] Pipes [Function] Carry fluids [Molecular example(s)]
Various tubular structures
[]
ENGINES of CREATION 2.0 | Molecular Engineering: An Approach to the Development of General Capabilities for Molecular Manipulation | KurzweilAI
Molecular example(s)
http://www.kurzweilai.net/engines-of-creation-2-molecular-engineering-approach
21/1438042988840.31_20150728002308-00039-ip-10-236-191-2_549821761_0.json
82a9d63b_ular_Manipulation___KurzweilAI__Molecular_example_s_
[Technology] Pumps [Function] Move fluids [Molecular example(s)]
Flagella, membrane proteins
[]
ENGINES of CREATION 2.0 | Molecular Engineering: An Approach to the Development of General Capabilities for Molecular Manipulation | KurzweilAI
Molecular example(s)
http://www.kurzweilai.net/engines-of-creation-2-molecular-engineering-approach
21/1438042988840.31_20150728002308-00039-ip-10-236-191-2_549821761_0.json
82a9d63b_ular_Manipulation___KurzweilAI__Molecular_example_s_
[Technology] Conveyor belts [Function] Move components [Molecular example(s)]
RNA moved by fixed ribosome (partial analog)
[]
ENGINES of CREATION 2.0 | Molecular Engineering: An Approach to the Development of General Capabilities for Molecular Manipulation | KurzweilAI
Molecular example(s)
http://www.kurzweilai.net/engines-of-creation-2-molecular-engineering-approach
21/1438042988840.31_20150728002308-00039-ip-10-236-191-2_549821761_0.json
82a9d63b_ular_Manipulation___KurzweilAI__Molecular_example_s_
[Technology] Clamps [Function] Hold workpieces [Molecular example(s)]
Enzymatic binding sites
[]
ENGINES of CREATION 2.0 | Molecular Engineering: An Approach to the Development of General Capabilities for Molecular Manipulation | KurzweilAI
Molecular example(s)
http://www.kurzweilai.net/engines-of-creation-2-molecular-engineering-approach
21/1438042988840.31_20150728002308-00039-ip-10-236-191-2_549821761_0.json
82a9d63b_ular_Manipulation___KurzweilAI__Molecular_example_s_
[Technology] Tools [Function] Modify workpieces [Molecular example(s)]
Metallic complexes, functional groups
[]
ENGINES of CREATION 2.0 | Molecular Engineering: An Approach to the Development of General Capabilities for Molecular Manipulation | KurzweilAI
Molecular example(s)
http://www.kurzweilai.net/engines-of-creation-2-molecular-engineering-approach
21/1438042988840.31_20150728002308-00039-ip-10-236-191-2_549821761_0.json
82a9d63b_ular_Manipulation___KurzweilAI__Molecular_example_s_
[Technology] Production lines [Function] Construct devices [Molecular example(s)]
Enzyme systems, ribosomes
[]
ENGINES of CREATION 2.0 | Molecular Engineering: An Approach to the Development of General Capabilities for Molecular Manipulation | KurzweilAI
Molecular example(s)
http://www.kurzweilai.net/engines-of-creation-2-molecular-engineering-approach
21/1438042988840.31_20150728002308-00039-ip-10-236-191-2_549821761_0.json
82a9d63b_ular_Manipulation___KurzweilAI__Molecular_example_s_
[Technology] Numerical control systems [Function] Store and read programs [Molecular example(s)]
Genetic system
[]
ENGINES of CREATION 2.0 | Molecular Engineering: An Approach to the Development of General Capabilities for Molecular Manipulation | KurzweilAI
Molecular example(s)
http://www.kurzweilai.net/engines-of-creation-2-molecular-engineering-approach
21/1438042988840.31_20150728002308-00039-ip-10-236-191-2_549821761_0.json
f631724c_Hair_Replacement___hair4all__Hair_Systems
[Wigs, Hairpieces, Toupeees] Poor quality hair that is dull, brittle, loses colour and has stiff movement. [Hair Systems]
High quality human hair with the most natural shine, strength, colour retainment and real movement.
[]
Hair Replacement - hair4all
Hair Systems
http://www.hair4all.com/hair/
21/1438042987174.71_20150728002307-00332-ip-10-236-191-2_473147304_0.json
f631724c_Hair_Replacement___hair4all__Hair_Systems
[Wigs, Hairpieces, Toupeees] Base materials are unnatural looking, heavy and uncomfortable. [Hair Systems]
Highly transparent skin or lace materials that are thin and lightweight. They enable the scalp to breathe and the hair to move like natural hair.
[]
Hair Replacement - hair4all
Hair Systems
http://www.hair4all.com/hair/
21/1438042987174.71_20150728002307-00332-ip-10-236-191-2_473147304_0.json
f631724c_Hair_Replacement___hair4all__Hair_Systems
[Wigs, Hairpieces, Toupeees] Heavy hair density to hide underlying base materials. [Hair Systems]
The highly transparent bases enable very light densities to be used. The bases take on the tone of your scalp making the hair appear to be growing out of your scalp.
[]
Hair Replacement - hair4all
Hair Systems
http://www.hair4all.com/hair/
21/1438042987174.71_20150728002307-00332-ip-10-236-191-2_473147304_0.json
f631724c_Hair_Replacement___hair4all__Hair_Systems
[Wigs, Hairpieces, Toupeees] Unsightly frontal hairlines. [Hair Systems]
Lace fronts and skin systems with graduated thickness give the most natural hairlines even under close scrutiny.
[]
Hair Replacement - hair4all
Hair Systems
http://www.hair4all.com/hair/
21/1438042987174.71_20150728002307-00332-ip-10-236-191-2_473147304_0.json
f631724c_Hair_Replacement___hair4all__Hair_Systems
[Wigs, Hairpieces, Toupeees] Mismatch to natural hair. [Hair Systems]
All aspects of your hair (including colour) are matched to ensure your hair system integrates with your natural hair. We even match colour blends such as greys.
[]
Hair Replacement - hair4all
Hair Systems
http://www.hair4all.com/hair/
21/1438042987174.71_20150728002307-00332-ip-10-236-191-2_473147304_0.json
f631724c_Hair_Replacement___hair4all__Hair_Systems
[Wigs, Hairpieces, Toupeees] Poorly fitting due to being mass manufactured and sold off the shelf. [Hair Systems]
Individually customised and manufactured to fit your scalp.
[]
Hair Replacement - hair4all
Hair Systems
http://www.hair4all.com/hair/
21/1438042987174.71_20150728002307-00332-ip-10-236-191-2_473147304_0.json
cf7ea097_Divider_Strips__Zinc
[Contaminate] Muriatic Acid, as frequently used for cleaning terrazzo [TESCO Alloy] No Effect [Zinc]
Effected
[ [ "E", "f", "f", "e", "c", "t", "e", "d" ], [ "S", "l", "i", "g", "h", "t", " ", "E", "f", "f", "e", "c", "t" ], [ "N", "o", " ", "E", "f", "f", "e", "c", "t" ], [ ".", "2", " ", "M", "i", "l", "s", " ", "p", "r", "/", "y", "r" ] ]
Divider Strips
Zinc
http://www.tescoproductsinc.com/Tesco2012/divider_strips.html
21/1438042988840.31_20150728002308-00162-ip-10-236-191-2_749528927_2.json
cf7ea097_Divider_Strips__Zinc
[Contaminate] Light Salt Solutions, such a Calcium Chloride [TESCO Alloy] No Effect [Zinc]
Effected
[ [ "E", "f", "f", "e", "c", "t", "e", "d" ], [ "S", "l", "i", "g", "h", "t", " ", "E", "f", "f", "e", "c", "t" ], [ "N", "o", " ", "E", "f", "f", "e", "c", "t" ], [ ".", "2", " ", "M", "i", "l", "s", " ", "p", "r", "/", "y", "r" ] ]
Divider Strips
Zinc
http://www.tescoproductsinc.com/Tesco2012/divider_strips.html
21/1438042988840.31_20150728002308-00162-ip-10-236-191-2_749528927_2.json
cf7ea097_Divider_Strips__Zinc
[Contaminate] Light Alkaline Solution [TESCO Alloy] Slight Effect [Zinc]
Slight Effect
[ [ "E", "f", "f", "e", "c", "t", "e", "d" ], [ "S", "l", "i", "g", "h", "t", " ", "E", "f", "f", "e", "c", "t" ], [ "N", "o", " ", "E", "f", "f", "e", "c", "t" ], [ ".", "2", " ", "M", "i", "l", "s", " ", "p", "r", "/", "y", "r" ] ]
Divider Strips
Zinc
http://www.tescoproductsinc.com/Tesco2012/divider_strips.html
21/1438042988840.31_20150728002308-00162-ip-10-236-191-2_749528927_2.json
cf7ea097_Divider_Strips__Zinc
[Contaminate] Urine [TESCO Alloy] No Effect [Zinc]
Effected
[ [ "E", "f", "f", "e", "c", "t", "e", "d" ], [ "S", "l", "i", "g", "h", "t", " ", "E", "f", "f", "e", "c", "t" ], [ "N", "o", " ", "E", "f", "f", "e", "c", "t" ], [ ".", "2", " ", "M", "i", "l", "s", " ", "p", "r", "/", "y", "r" ] ]
Divider Strips
Zinc
http://www.tescoproductsinc.com/Tesco2012/divider_strips.html
21/1438042988840.31_20150728002308-00162-ip-10-236-191-2_749528927_2.json
cf7ea097_Divider_Strips__Zinc
[Contaminate] Blood [TESCO Alloy] No Effect [Zinc]
No Effect
[ [ "E", "f", "f", "e", "c", "t", "e", "d" ], [ "S", "l", "i", "g", "h", "t", " ", "E", "f", "f", "e", "c", "t" ], [ "N", "o", " ", "E", "f", "f", "e", "c", "t" ], [ ".", "2", " ", "M", "i", "l", "s", " ", "p", "r", "/", "y", "r" ] ]
Divider Strips
Zinc
http://www.tescoproductsinc.com/Tesco2012/divider_strips.html
21/1438042988840.31_20150728002308-00162-ip-10-236-191-2_749528927_2.json
cf7ea097_Divider_Strips__Zinc
[Contaminate] Cleaning Preparation, juices, oils, tea, coffee, butter, mayonnaise, vinegar, shortening, etc. [TESCO Alloy] No Effect [Zinc]
No Effect
[ [ "E", "f", "f", "e", "c", "t", "e", "d" ], [ "S", "l", "i", "g", "h", "t", " ", "E", "f", "f", "e", "c", "t" ], [ "N", "o", " ", "E", "f", "f", "e", "c", "t" ], [ ".", "2", " ", "M", "i", "l", "s", " ", "p", "r", "/", "y", "r" ] ]
Divider Strips
Zinc
http://www.tescoproductsinc.com/Tesco2012/divider_strips.html
21/1438042988840.31_20150728002308-00162-ip-10-236-191-2_749528927_2.json
cf7ea097_Divider_Strips__Zinc
[Contaminate] Gasoline [TESCO Alloy] No Effect [Zinc]
No Effect
[ [ "E", "f", "f", "e", "c", "t", "e", "d" ], [ "S", "l", "i", "g", "h", "t", " ", "E", "f", "f", "e", "c", "t" ], [ "N", "o", " ", "E", "f", "f", "e", "c", "t" ], [ ".", "2", " ", "M", "i", "l", "s", " ", "p", "r", "/", "y", "r" ] ]
Divider Strips
Zinc
http://www.tescoproductsinc.com/Tesco2012/divider_strips.html
21/1438042988840.31_20150728002308-00162-ip-10-236-191-2_749528927_2.json
cf7ea097_Divider_Strips__Zinc
[Contaminate] Trichloroethylene [TESCO Alloy] No Effectt [Zinc]
No Effect
[ [ "E", "f", "f", "e", "c", "t", "e", "d" ], [ "S", "l", "i", "g", "h", "t", " ", "E", "f", "f", "e", "c", "t" ], [ "N", "o", " ", "E", "f", "f", "e", "c", "t" ], [ ".", "2", " ", "M", "i", "l", "s", " ", "p", "r", "/", "y", "r" ] ]
Divider Strips
Zinc
http://www.tescoproductsinc.com/Tesco2012/divider_strips.html
21/1438042988840.31_20150728002308-00162-ip-10-236-191-2_749528927_2.json
cf7ea097_Divider_Strips__Zinc
[Contaminate] Highly Industrial Atmospheres Penetration (1 Mil=0.001 inch) [TESCO Alloy] .2 Mils pr/yr [Zinc]
.2 Mils pr/yr
[ [ "E", "f", "f", "e", "c", "t", "e", "d" ], [ "S", "l", "i", "g", "h", "t", " ", "E", "f", "f", "e", "c", "t" ], [ "N", "o", " ", "E", "f", "f", "e", "c", "t" ], [ ".", "2", " ", "M", "i", "l", "s", " ", "p", "r", "/", "y", "r" ] ]
Divider Strips
Zinc
http://www.tescoproductsinc.com/Tesco2012/divider_strips.html
21/1438042988840.31_20150728002308-00162-ip-10-236-191-2_749528927_2.json
02904b29_Domestic_and_Fancy_Rat__Adult_Mouse
[Feature] Head [Baby Rat] short, stubby, broad, large relative to body [Adult Mouse]
small, triangular, small relative to body
[]
Domestic and Fancy Rat
Adult Mouse
http://www.mosciencecamp.com/domestic-and-fancy-rat
21/1438043062635.98_20150728002422-00215-ip-10-236-191-2_584095770_1.json
02904b29_Domestic_and_Fancy_Rat__Adult_Mouse
[Feature] Muzzle [Baby Rat] large and blunt with wide muzzle [Adult Mouse]
narrow with sharp muzzle
[]
Domestic and Fancy Rat
Adult Mouse
http://www.mosciencecamp.com/domestic-and-fancy-rat
21/1438043062635.98_20150728002422-00215-ip-10-236-191-2_584095770_1.json
02904b29_Domestic_and_Fancy_Rat__Adult_Mouse
[Feature] Ears [Baby Rat] ears are small relative to the head [Adult Mouse]
ears are large relative to the head
[]
Domestic and Fancy Rat
Adult Mouse
http://www.mosciencecamp.com/domestic-and-fancy-rat
21/1438043062635.98_20150728002422-00215-ip-10-236-191-2_584095770_1.json
02904b29_Domestic_and_Fancy_Rat__Adult_Mouse
[Feature] Tail [Baby Rat] thick [Adult Mouse]
thin
[]
Domestic and Fancy Rat
Adult Mouse
http://www.mosciencecamp.com/domestic-and-fancy-rat
21/1438043062635.98_20150728002422-00215-ip-10-236-191-2_584095770_1.json
02904b29_Domestic_and_Fancy_Rat__Adult_Mouse
[Feature] Tail/body ratio [Baby Rat] Tail shorter than body [Adult Mouse]
Tail same length/longer than body
[]
Domestic and Fancy Rat
Adult Mouse
http://www.mosciencecamp.com/domestic-and-fancy-rat
21/1438043062635.98_20150728002422-00215-ip-10-236-191-2_584095770_1.json
02904b29_Domestic_and_Fancy_Rat__Adult_Mouse
[Feature] Feet [Baby Rat] Large relative to body, especially the hind feet [Adult Mouse]
Small relative to body
[]
Domestic and Fancy Rat
Adult Mouse
http://www.mosciencecamp.com/domestic-and-fancy-rat
21/1438043062635.98_20150728002422-00215-ip-10-236-191-2_584095770_1.json
02904b29_Domestic_and_Fancy_Rat__Adult_Mouse
[Feature] Weight [Baby Rat] around 100 grams at 6 weeks, 200 grams at 8 weeks [Adult Mouse]
30-50 grams
[]
Domestic and Fancy Rat
Adult Mouse
http://www.mosciencecamp.com/domestic-and-fancy-rat
21/1438043062635.98_20150728002422-00215-ip-10-236-191-2_584095770_1.json
02904b29_Domestic_and_Fancy_Rat__Adult_Mouse
[Baby Rat] 6 week old rat [Adult Mouse]
Adult mouse
[]
Domestic and Fancy Rat
Adult Mouse
http://www.mosciencecamp.com/domestic-and-fancy-rat
21/1438043062635.98_20150728002422-00215-ip-10-236-191-2_584095770_1.json
04d0c4d7__characterisation_of_risk_loci__0
[1] Description [2] Host/ Applications [3] Advantages/ disadvantages [4] Technical challenges, References, and Resources [0]
Approach
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WikiGenes - Principles for the post-GWAS functional characterisation of risk loci
0
http://www.wikigenes.org/e/pub/e/84.html
21/1438042988840.31_20150728002308-00177-ip-10-236-191-2_832372978_0.json
04d0c4d7__characterisation_of_risk_loci__0
[1] Modification of cell’s or organism’s genotype to assess allele-specific effects using targeted recombination vectors [2] Cell lines: Manipulation of cell’s genotype by introduction/changes in specific SNPs into cell lines (e.g. colorectal cancer HCT116 cell line). [3] Cell lines can be used for biochemistry studies, drug response screens, short and long term cell biological assays (e.g. apoptosis, survival fraction assays, soft agar growth assays). Limitations include the inability to assess effects from the in vivo milieu or developmentally-restricted effects. [4] Relatively low frequency of integration necessitating the screening of a large number of clones. Efficiency of integration may be gene specific as it depends on the structure of the homology fragments flanking the target locus. While a targeting vector with a G418r (or Hygr) cassette driven by the phosphoglycerate kinase promoter can be effectively used to target regulatory regions, it is expected to increase the number of random events References and resources: [153][154][155][156][157] _ENREF_2[158][159][160][161] [0]
Homologous recombination
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WikiGenes - Principles for the post-GWAS functional characterisation of risk loci
0
http://www.wikigenes.org/e/pub/e/84.html
21/1438042988840.31_20150728002308-00177-ip-10-236-191-2_832372978_0.json
04d0c4d7__characterisation_of_risk_loci__0
[1] DNA-binding nucleases that can be used for genomic editing. It creates DSBs at specified sites which are normally repaired by error-prone NHEJ. A transfected template including a mutation favors homology-directed recombination leading to a knock-in of the desired mutation. [2] Cell lines: Manipulation of cell’s genotype by introduction/changes in specific SNPs into cell lines (e.g. myelogenous leukaemia K562 cell line). [3] Same as described for cell lines (see above) [4] The generation of a DSB leads to a high frequency of modified clones. Challenges include limited availability of off-the-shelf cell lines and very high cost. References and resources: [162][163] [0]
Gene targeting by zinc finger nucleases
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WikiGenes - Principles for the post-GWAS functional characterisation of risk loci
0
http://www.wikigenes.org/e/pub/e/84.html
21/1438042988840.31_20150728002308-00177-ip-10-236-191-2_832372978_0.json
04d0c4d7__characterisation_of_risk_loci__0
[1] Silencing of gene expression using plasmid-encoded short hairpin RNAs (shRNAs) or double stranded RNA (dsRNAs) [2] Cell lines: Manipulation of expression levels of associated genes to monitor its effects. [3] Easier and faster than homologous recombination. Lentiviral/adenoviral delivery generates high transduction efficiencies and can be done transiently or stably. Results may depend on the effectiveness of shRNA. While there are clear advantages of using stable cell lines they may adapt to the knock down by acquiring additional mutations or the stable knock down might be incompatible with viability. Thus, both approaches should be exploited. [4] There are now several commercially available sources of validated shRNAs, developed by the RNAi Consortium, cloned in lentiviral vectors that can be packaged by 293FT into replication-defective lentivirus. Thoughtful controls should be applied to rule out off-target effects. References and resources: [166] [0]
RNA interference
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WikiGenes - Principles for the post-GWAS functional characterisation of risk loci
0
http://www.wikigenes.org/e/pub/e/84.html
21/1438042988840.31_20150728002308-00177-ip-10-236-191-2_832372978_0.json
04d0c4d7__characterisation_of_risk_loci__0
[1] Artificially synthesized molecule with redesign of natural nucleic acid structure that is used to modify gene expression. [2] Embryos, organs or eggs manipulation, from Zebrafish, mouse and other organisms [3] Very convenient techniques for developmental studies on embryonic stage, or in vitro organ. much more stable than conventional SiRNA techniques. [4] Morpholino oligomers block small (~25 base) regions of the base-pairing surfaces of ribonucleic acid (RNA). References and resources: [167] [0]
Morpholino
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WikiGenes - Principles for the post-GWAS functional characterisation of risk loci
0
http://www.wikigenes.org/e/pub/e/84.html
21/1438042988840.31_20150728002308-00177-ip-10-236-191-2_832372978_0.json
04d0c4d7__characterisation_of_risk_loci__0
[1] Transient or stable transfection mediated by plasmid or lentiviral expression vectors. [2] Cell lines: Modulation of expression levels achieved often using constructs with strong promoters (e.g. CMV) but tissue-specific and inducible promoters can also be used to modulate gene expression. [3] Fast, easy, economical and reproducible. However, it is often difficult to obtain an expression comparable to physiologic levels or in a cell cycle-specific pattern. There may be artifactual effects resulting from over-expression. [4] Analysis should be performed in pools as well as in multiple clonal isolates to control for clonal variation or adaptation. References and resources: [168] [0]
Ectopic gene over-expression
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WikiGenes - Principles for the post-GWAS functional characterisation of risk loci
0
http://www.wikigenes.org/e/pub/e/84.html
21/1438042988840.31_20150728002308-00177-ip-10-236-191-2_832372978_0.json
04d0c4d7__characterisation_of_risk_loci__0
[1] Multiplex miniaturized technology consisting of an arrayed series of thousands of microscopic spots (probes); they can be small regions of a gene used to hybridize a DNA or a RNA sample quantified by the detection of fluorescence. [2] Sources: DNA or RNA from any biological sources (cell lines, biopsies, blood or other body fluids). Applications: Gene expression profiles, Comparative Genomic Hybridisation, epigenetic modification, SNPs analysis and Aternative Splicing detection at the genome scale. [3] Fast and genome-wide application but require different controls to avoid the occurrence of false positive or negative data. Deep bioinformatic analyses are also needed. [4] According to the type of the array, quality composition of the slides must be carefully designed. Some additional specific experiments are often required to validate the results obtained. References and resources: [169] [0]
Microarrays not only limited to cDNA RNA and DNA for classical genomy and expression analysis, but also expand into epigenetic field.
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WikiGenes - Principles for the post-GWAS functional characterisation of risk loci
0
http://www.wikigenes.org/e/pub/e/84.html
21/1438042988840.31_20150728002308-00177-ip-10-236-191-2_832372978_0.json
04d0c4d7__characterisation_of_risk_loci__0
[1] High throughput next-generation sequencing of cDNA libraries generated either from the entire set of cellular steady-state RNA or its subsets. [2] Applications: (i) Discovery of novel RNA species including long non-coding RNA and small regulatory RNA, as well as new RNA isoforms originating from known loci; (ii) whole-transcriptome expression profiling including eQTL discovery; (iii) targeted transcription profiling within GWAS regions. [3] Advantages: Eliminates dependence on probes used in Microarray applications; enables quantitative profiling of the entire transcriptome and its subsets. Higher dynamic range and sensitivity. Higher power to distinguish smaller changes in gene expression. Capacity for detecting allele-specific expression. Enables direct detection of RNA splice isoforms. Genetic variations including SNPs, CNVs and translocations canbe detected in the same experiment. Disadvantages: High costs prohibits large scale eQTL projects. [4] Although RNA-seq allows for potentially limitless dynamic range there is a strong effect of diminishing return for detection of RNA with low abundance, as very large portion of sequence reads is taken up by most abundant RNA transcripts. Transcriptome partitioning utilizing either enrichment or depletion techniques (e.g. rRNA depletion or small RNA enrichment) largely alleviates this problem. Data analysis methodologies are rapidly maturing but still represent a significant challenge. [170] [87] [171] [172] [0]
RNA-Seq
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WikiGenes - Principles for the post-GWAS functional characterisation of risk loci
0
http://www.wikigenes.org/e/pub/e/84.html
21/1438042988840.31_20150728002308-00177-ip-10-236-191-2_832372978_0.json
04d0c4d7__characterisation_of_risk_loci__0
[1] c-Myc, KLF4, Oct4, Sox2 and possibly others could transform cells, via retroviral/adenoviral/plasmid, into ES-like stem cells (iPSC), enabling experimentation in these cell lines. [2] Cell lines. Manipulation of cells' genotype by introducing specific SNPs and consequent observation. [3] Can be studied for apoptosis, tumor formation etc. [4] Of uncertain yield. [0]
Transcription factors I strongly suggest this is not qualified as a technical approach
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WikiGenes - Principles for the post-GWAS functional characterisation of risk loci
0
http://www.wikigenes.org/e/pub/e/84.html
21/1438042988840.31_20150728002308-00177-ip-10-236-191-2_832372978_0.json
04d0c4d7__characterisation_of_risk_loci__0
[1] By using histone deacetylase inhibitors (HDAC inhibitors) like all-trans retinoic acid (ATRA) and DNA methyltransferase inhibitors. [2] Cell lines and animal models. Retinoic acid induces epigenetic modification. [0]
Pharmacologic intervention of epigenetic control
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WikiGenes - Principles for the post-GWAS functional characterisation of risk loci
0
http://www.wikigenes.org/e/pub/e/84.html
21/1438042988840.31_20150728002308-00177-ip-10-236-191-2_832372978_0.json
f0719fe3_ents_content_from_New_Hope_360__Weight_loss_effect
[0] 7-keto DHEA 100% [Weight loss effect]
May provide additional weight loss in overweight people on calorie-reduced diets.
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Which weight loss supplements are best? | Ingredients content from New Hope 360
Weight loss effect
http://newhope360.com/ingredients/which-weight-loss-supplements-are-best
21/1438042987174.71_20150728002307-00118-ip-10-236-191-2_174260567_0.json
f0719fe3_ents_content_from_New_Hope_360__Weight_loss_effect
[0] CLA (conjugated linoleic acid) 75% [Weight loss effect]
May help with slimming by increasing proportion of lean body mass to fat.
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Which weight loss supplements are best? | Ingredients content from New Hope 360
Weight loss effect
http://newhope360.com/ingredients/which-weight-loss-supplements-are-best
21/1438042987174.71_20150728002307-00118-ip-10-236-191-2_174260567_0.json
f0719fe3_ents_content_from_New_Hope_360__Weight_loss_effect
[0] Garcinia cambogia extract 46% [Weight loss effect]
May cause modest weight loss. Appears to work better in women than men and when person is not markedly obese.
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Which weight loss supplements are best? | Ingredients content from New Hope 360
Weight loss effect
http://newhope360.com/ingredients/which-weight-loss-supplements-are-best
21/1438042987174.71_20150728002307-00118-ip-10-236-191-2_174260567_0.json
f0719fe3_ents_content_from_New_Hope_360__Weight_loss_effect
[0] Green coffee bean extract 50% [Weight loss effect]
May cause modest weight loss.
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Which weight loss supplements are best? | Ingredients content from New Hope 360
Weight loss effect
http://newhope360.com/ingredients/which-weight-loss-supplements-are-best
21/1438042987174.71_20150728002307-00118-ip-10-236-191-2_174260567_0.json
f0719fe3_ents_content_from_New_Hope_360__Weight_loss_effect
[0] Green tea extract 75% [Weight loss effect]
May aid weight loss and protect against weight gain.
[]
Which weight loss supplements are best? | Ingredients content from New Hope 360
Weight loss effect
http://newhope360.com/ingredients/which-weight-loss-supplements-are-best
21/1438042987174.71_20150728002307-00118-ip-10-236-191-2_174260567_0.json
f0719fe3_ents_content_from_New_Hope_360__Weight_loss_effect
[0] Herbal stimulant blends None approved (due to potentially dangerous high caffeine content) [Weight loss effect]
Caffeine from herbs may help with weight loss.
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Which weight loss supplements are best? | Ingredients content from New Hope 360
Weight loss effect
http://newhope360.com/ingredients/which-weight-loss-supplements-are-best
21/1438042987174.71_20150728002307-00118-ip-10-236-191-2_174260567_0.json
6f4a424d__Reviews___Does_Exposed_WORK____Benefit
[0] 1 [Feature] A corrective and preventive acne system [Benefit]
Along with treating existing acne, Exposed also helps prevent future acne.
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Exposed Skin Care Reviews - Does Exposed WORK ?
Benefit
http://www.bestacnetreatment.org/exposed-skin-care/
21/1438043062635.98_20150728002422-00330-ip-10-236-191-2_310960834_4.json
6f4a424d__Reviews___Does_Exposed_WORK____Benefit
[0] 2 [Feature] A natural , herbal + scientific remedy [Benefit]
Free of side effects, risk of drug interactions and complications even after long-term use
[]
Exposed Skin Care Reviews - Does Exposed WORK ?
Benefit
http://www.bestacnetreatment.org/exposed-skin-care/
21/1438043062635.98_20150728002422-00330-ip-10-236-191-2_310960834_4.json
6f4a424d__Reviews___Does_Exposed_WORK____Benefit
[0] 3 [Feature] Multi-component system consisting of multiple products [Benefit]
Ensures complete skin care at all levels and takes care of acne of all types
[]
Exposed Skin Care Reviews - Does Exposed WORK ?
Benefit
http://www.bestacnetreatment.org/exposed-skin-care/
21/1438043062635.98_20150728002422-00330-ip-10-236-191-2_310960834_4.json
6f4a424d__Reviews___Does_Exposed_WORK____Benefit
[0] 4 [Feature] Versatile product [Benefit]
Treats all kinds of acne lesions and relieves mild to moderate acne as well as more serious acne that creates nodules and cysts
[]
Exposed Skin Care Reviews - Does Exposed WORK ?
Benefit
http://www.bestacnetreatment.org/exposed-skin-care/
21/1438043062635.98_20150728002422-00330-ip-10-236-191-2_310960834_4.json
6f4a424d__Reviews___Does_Exposed_WORK____Benefit
[0] 5 [Feature] High safety profile [Benefit]
With no continual side effects for its users; men and women using Exposed Skin Care system will see no excessive dryness to the skin while treating redness, irritation, itching, inflammation and scarring
[]
Exposed Skin Care Reviews - Does Exposed WORK ?
Benefit
http://www.bestacnetreatment.org/exposed-skin-care/
21/1438043062635.98_20150728002422-00330-ip-10-236-191-2_310960834_4.json
6f4a424d__Reviews___Does_Exposed_WORK____Benefit
[0] 6 [Feature] Full-year money back guarantee for any customer who is dissatisfied with their product. [Benefit]
Peace of mind with no financial risk involved
[]
Exposed Skin Care Reviews - Does Exposed WORK ?
Benefit
http://www.bestacnetreatment.org/exposed-skin-care/
21/1438043062635.98_20150728002422-00330-ip-10-236-191-2_310960834_4.json
6f4a424d__Reviews___Does_Exposed_WORK____Benefit
[0] 7 [Feature] Official customer support [Benefit]
24/7 call center and an online customer support system where customers can ask questions and/or order products
[]
Exposed Skin Care Reviews - Does Exposed WORK ?
Benefit
http://www.bestacnetreatment.org/exposed-skin-care/
21/1438043062635.98_20150728002422-00330-ip-10-236-191-2_310960834_4.json
6f4a424d__Reviews___Does_Exposed_WORK____Benefit
[0] 8 [Feature] Official website (www.exposedskincare.com/) [Benefit]
Product can be safely, securely and confidentially bought from the company’s own official website
[]
Exposed Skin Care Reviews - Does Exposed WORK ?
Benefit
http://www.bestacnetreatment.org/exposed-skin-care/
21/1438043062635.98_20150728002422-00330-ip-10-236-191-2_310960834_4.json
bacbbe5f_elphia_County_Master_Gardeners__How_to_DIY
[Management Method] Horticultural (Insecticidal) Soap [Who/What it Manages] Fungus Gnats, Whiteflies, Mealybugs, Aphids, Spider Mites (soft bodied insects) [How to DIY]
Using original Dawn brand or Liquid Joy liquid soap only (nothing with additional power or chemicals): Combine 1 cup of vegetable oil with 1tbs liquid soap. Mix well. Dilute the mixture by combining 2tsps of the oil/soap solution per 1 cup warm (filtered) water and put into a spray bottle. Mix only what you’ll use in that day. Do not store. Spray leaves above and below. Shade for 24 hours after treatment to prevent burn. ! Commercial soap sprays are effective and if you read the label, you can find non-chemical based sprays that are premixed and have a longer shelf life.
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Philadelphia County Master Gardeners
How to DIY
http://philadelphiacountymastergardeners.blogspot.com/
21/1438042988840.31_20150728002308-00283-ip-10-236-191-2_190481664_8.json
bacbbe5f_elphia_County_Master_Gardeners__How_to_DIY
[Management Method] Yellow “Sticky Traps” [Who/What it Manages] Whitefly, aphids, thrips, leafhoppers, moths, fruit flies, fungus gnats [How to DIY]
Use yellow poster board or color an index card with yellow marker. Cut into 1”x3” pieces. Fold in half around a toothpick. Secure (I use glue stick) Paint with honey or petroleum jelly on both sides of flag. Push toothpick into soil. Insects will stick and die. Replace when there’s more full space than empty space on card.
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Philadelphia County Master Gardeners
How to DIY
http://philadelphiacountymastergardeners.blogspot.com/
21/1438042988840.31_20150728002308-00283-ip-10-236-191-2_190481664_8.json
bacbbe5f_elphia_County_Master_Gardeners__How_to_DIY
[Management Method] Bury Garlic Bulbs [Who/What it Manages] Burying a piece of Mother Nature’s natural insect repellent! Burying garlic, is a Farmer’s Almanac-style trick to eradicate pests from houseplants. Garlic is a natural repellent to large numbers of soil & leaf loving pests. Too many to list. [How to DIY]
Using one clove of garlic per pot, bury the clove into the soil about halfway. If garlic begins to sprout, pull and transplant in garden then replace or allow to grow, trimming back the green shoots. Replace monthly for best effects. You can use the garlic clove with or without the skin.
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Philadelphia County Master Gardeners
How to DIY
http://philadelphiacountymastergardeners.blogspot.com/
21/1438042988840.31_20150728002308-00283-ip-10-236-191-2_190481664_8.json
bacbbe5f_elphia_County_Master_Gardeners__How_to_DIY
[Management Method] Apple Cider Vinegar Trap [Who/What it Manages] Fruit flies, fungus gnats [How to DIY]
In a small container (I use a half-pint jar) fill with apple cider vinegar, cover tightly with plastic wrap and secure (I screw the jar rim over the plastic wrap but you can use rubber bands or tape) Poke small holes in top of plastic wrap and place near the most insect activity. Insects get in but can’t get out. Replace every 2 weeks, every 1 week in humid summer weather.
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Philadelphia County Master Gardeners
How to DIY
http://philadelphiacountymastergardeners.blogspot.com/
21/1438042988840.31_20150728002308-00283-ip-10-236-191-2_190481664_8.json
bacbbe5f_elphia_County_Master_Gardeners__How_to_DIY
[Management Method] Touch with Rubbing Alcohol (some say rubbing with a banana peel works too, but I’ve never tried it!) [Who/What it Manages] Spider Mites, aphids [How to DIY]
Dip a cotton ball or swab into a small dish of rubbing alcohol and lightly rub directly along plant stem and undersides of leaves where you see mite activity. Larger Scale Wash: Dip cloth into rubbing alcohol and lightly rub the entire plant. You can dilute with water for very delicate plants. DO NOT NEED MUCH! Lightly coat surface. Do not pour or create dripping. Shade for 24 hours after treatment.
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Philadelphia County Master Gardeners
How to DIY
http://philadelphiacountymastergardeners.blogspot.com/
21/1438042988840.31_20150728002308-00283-ip-10-236-191-2_190481664_8.json
bacbbe5f_elphia_County_Master_Gardeners__How_to_DIY
[Management Method] Submerge, Rinse & Repot (The old college try) [Who/What it Manages] A last ditch effort to rescue a plant from any pest, roots to tip of stem. [How to DIY]
If a plant is completely infested, pulling the plant from the pot and shaking off all excess soil and submerging the entire plant in room temperature water for up to 15 minutes will send many of the pests looking for higher ground and they will “float” away. Don’t be afraid to gently wipe the stems and corners to “bathe” the plant. Follow with a good rinsing and wiping of leaves then repot in clean potting mix. Follow up with a preventative treatment to keep potential eggs or stragglers from creating a new brood.
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Philadelphia County Master Gardeners
How to DIY
http://philadelphiacountymastergardeners.blogspot.com/
21/1438042988840.31_20150728002308-00283-ip-10-236-191-2_190481664_8.json
bacbbe5f_elphia_County_Master_Gardeners__How_to_DIY
[Management Method] Removal and Disposal (The last resort) [Who/What it Manages] Any Pest [How to DIY]
Sometimes the insects win, and in order to save the rest of your collection, a badly infected houseplant with severe damage that has not responded to your methods for management should be discarded (not in your compost bin where they can multiply).
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Philadelphia County Master Gardeners
How to DIY
http://philadelphiacountymastergardeners.blogspot.com/
21/1438042988840.31_20150728002308-00283-ip-10-236-191-2_190481664_8.json
96ad2a3c_allery_of_custom_built_guitars__1
[0] body [2] hardware [3] electronics [1]
neck
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Robert Fripp signature slim 'vine' guitar | Crimson Guitars UK_The Crimson Guitars gallery of custom built guitars
1
http://crimsonguitars.com/gallery/robert-fripp-slim-vine/
21/1438043062635.98_20150728002422-00329-ip-10-236-191-2_56926752_0.json
96ad2a3c_allery_of_custom_built_guitars__1
[0] 2 piece mahogany body [2] sperzel locking tuners [3] bespoke wizard humbucker at the bridge position [1]
mahogany multi-laminate neck
[ [ "n", "e", "c", "k" ], [ "m", "a", "h", "o", "g", "a", "n", "y", " ", "m", "u", "l", "t", "i", "-", "l", "a", "m", "i", "n", "a", "t", "e", " ", "n", "e", "c", "k" ], [ "d", "e", "e", "p", " ", "s", "e", "t", " ", "n", "e", "c", "k", " ", "t", "e", "n", "o", "n", " ", "d", "e", "s", "i", "g", "n" ], [ "e", "b", "o", "n", "y", " ", "f", "r", "e", "t", "b", "o", "a", "r", "d" ], [ "2", "2", " ", "s", "m", "a", "l", "l", " ", "f", "r", "e", "t", "s" ], [ "c", "o", "m", "p", "o", "u", "n", "d", " ", "f", "r", "e", "t", "b", "o", "a", "r", "d", " ", "r", "a", "d", "i", "u", "s" ], [ "2", "4", ".", "7", "5", "″", " ", "s", "c", "a", "l", "e", " ", "l", "e", "n", "g", "t", "h" ], [ "s", "i", "d", "e", " ", "d", "o", "t", "s", " ", "o", "n", "l", "y" ], [ "s", "l", "i", "m", " ", "n", "e", "c", "k", " ", "c", "a", "r", "v", "e" ] ]
Robert Fripp signature slim 'vine' guitar | Crimson Guitars UK_The Crimson Guitars gallery of custom built guitars
1
http://crimsonguitars.com/gallery/robert-fripp-slim-vine/
21/1438043062635.98_20150728002422-00329-ip-10-236-191-2_56926752_0.json
96ad2a3c_allery_of_custom_built_guitars__1
[0] 1 piece figured english elm top [2] wilkinson tremolo [3] dual rail single coil sized humbucker [1]
deep set neck tenon design
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Robert Fripp signature slim 'vine' guitar | Crimson Guitars UK_The Crimson Guitars gallery of custom built guitars
1
http://crimsonguitars.com/gallery/robert-fripp-slim-vine/
21/1438043062635.98_20150728002422-00329-ip-10-236-191-2_56926752_0.json
96ad2a3c_allery_of_custom_built_guitars__1
[0] high gloss lacquer finish [2] dual action truss rod [3] fernandes sustainer at the neck position [1]
ebony fretboard
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Robert Fripp signature slim 'vine' guitar | Crimson Guitars UK_The Crimson Guitars gallery of custom built guitars
1
http://crimsonguitars.com/gallery/robert-fripp-slim-vine/
21/1438043062635.98_20150728002422-00329-ip-10-236-191-2_56926752_0.json
96ad2a3c_allery_of_custom_built_guitars__1
[0] all access neck to body carve [2] chrome hardware [3] magnetic volume, tone and three way toggle [1]
22 small frets
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Robert Fripp signature slim 'vine' guitar | Crimson Guitars UK_The Crimson Guitars gallery of custom built guitars
1
http://crimsonguitars.com/gallery/robert-fripp-slim-vine/
21/1438043062635.98_20150728002422-00329-ip-10-236-191-2_56926752_0.json
96ad2a3c_allery_of_custom_built_guitars__1
[0] ergonomic body shaping [2] ghost piezo saddles [3] middle pickup separate volume and on/off toggle [1]
compound fretboard radius
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Robert Fripp signature slim 'vine' guitar | Crimson Guitars UK_The Crimson Guitars gallery of custom built guitars
1
http://crimsonguitars.com/gallery/robert-fripp-slim-vine/
21/1438043062635.98_20150728002422-00329-ip-10-236-191-2_56926752_0.json
96ad2a3c_allery_of_custom_built_guitars__1
[0] carved top [2] scalloped bone nut [3] sustainer on/off, three-way mode selection toggle [1]
24.75″ scale length
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Robert Fripp signature slim 'vine' guitar | Crimson Guitars UK_The Crimson Guitars gallery of custom built guitars
1
http://crimsonguitars.com/gallery/robert-fripp-slim-vine/
21/1438043062635.98_20150728002422-00329-ip-10-236-191-2_56926752_0.json
96ad2a3c_allery_of_custom_built_guitars__1
[0] multi-ply binding throughout [3] ghost acoustiphonic and hexaphonic active preamps [1]
side dots only
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Robert Fripp signature slim 'vine' guitar | Crimson Guitars UK_The Crimson Guitars gallery of custom built guitars
1
http://crimsonguitars.com/gallery/robert-fripp-slim-vine/
21/1438043062635.98_20150728002422-00329-ip-10-236-191-2_56926752_0.json
96ad2a3c_allery_of_custom_built_guitars__1
[3] MIDI up/down switch, MIDI/mix/piezo toggle, MIDI volume. [1]
slim neck carve
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Robert Fripp signature slim 'vine' guitar | Crimson Guitars UK_The Crimson Guitars gallery of custom built guitars
1
http://crimsonguitars.com/gallery/robert-fripp-slim-vine/
21/1438043062635.98_20150728002422-00329-ip-10-236-191-2_56926752_0.json
00a95e53_The_Winning_Weaning_Parameters__3
[0] Parameter [1] Normal Range [2] Indications for Weaning [3]
Definition
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The Winning Weaning Parameters
3
http://lungs4us.tripod.com/id21.htm
21/1438042988840.31_20150728002308-00251-ip-10-236-191-2_144186532_1.json
00a95e53_The_Winning_Weaning_Parameters__3
[0] Respiratory Rate [1] 10-20 breaths/min [2] <30 breaths/min* [3]
The number of respiration per minute. This includes all control, IMV/SIMV and spontaneous respiration. An elevated respiratory rate is the compensating mechanism for a drop of tidal volume as a result of increased body exertion. This increase, outside the normal range, is a possible indicator of the onset of fatigue associated with the failure of the ventilatory pump to maintain adequate output in the face of the imposed workload. A low respiratory rate may result in hypoventilation and a respiratory acidosis.
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The Winning Weaning Parameters
3
http://lungs4us.tripod.com/id21.htm
21/1438042988840.31_20150728002308-00251-ip-10-236-191-2_144186532_1.json
00a95e53_The_Winning_Weaning_Parameters__3
[0] Delta Esophageal Pressure [1] 5-10 cmH2O [2] <15 cmH2O [3]
Delta Esophageal Pressure is the pressure change in the esophagus due to ventilation. This measurement has been reported to accurately track changes in the pleural pressure. During any ventilation activity, airway pressures maybe transmitted across the pleural space to the esophagus. On patient initiated breaths, the true value of Delta Esophageal Pressure is the negative deflection of the esophageal pressure. On assisted breath during mechanical support or during controlled mechanical ventilation, positive airway pressure may be transmitted across the potential space causing a rise in esophageal pressure above the normal end esophageal pressure point. Delta Esophageal Pressure is an excellent weaning indicator. Normal Range for non-ventilated patient is 2-10 cmH2O
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The Winning Weaning Parameters
3
http://lungs4us.tripod.com/id21.htm
21/1438042988840.31_20150728002308-00251-ip-10-236-191-2_144186532_1.json
00a95e53_The_Winning_Weaning_Parameters__3
[0] Tidal Volume [1] 7-10 ml/kg [2] >5 ml/kg* [3]
Tidal Volume is the volume of inhaled (VTins) or exhaled (VTexp)gas per each breath. This is monitored during mechanical ventilation to determine if the level of mechanical support is adequate for the patient. It may also be an indicator of respiratory fatigue
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The Winning Weaning Parameters
3
http://lungs4us.tripod.com/id21.htm
21/1438042988840.31_20150728002308-00251-ip-10-236-191-2_144186532_1.json
00a95e53_The_Winning_Weaning_Parameters__3
[0] Vital Capacity [1] >15 ml/kg [3]
Yes, you should know this by now!
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The Winning Weaning Parameters
3
http://lungs4us.tripod.com/id21.htm
21/1438042988840.31_20150728002308-00251-ip-10-236-191-2_144186532_1.json
00a95e53_The_Winning_Weaning_Parameters__3
[0] Minute Ventilation [1] 5-10 liters/minute [2] <10 liters/minute [3]
This one too!
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The Winning Weaning Parameters
3
http://lungs4us.tripod.com/id21.htm
21/1438042988840.31_20150728002308-00251-ip-10-236-191-2_144186532_1.json
00a95e53_The_Winning_Weaning_Parameters__3
[0] TI / TTOT Respiratory Time Fraction [1] .3-.4 [2] Increase of >.1* [3]
Respiratory Time Fraction (TI / TTOT) indicates endurance and is defined as the ratio of the inspired time to the total time of the respiratory cycle. This value is a ratio and there is no unit of measure. As the respiratory muscles fatigue, the fraction of the breathing cycle spent in inspiration tends to increase. When there is respiratory muscle fatigue and impending respiratory failure the ratio between inspiratory time and total time available for the breath may incrementally increase to a point in which the respiratory pump can no longer maintain itself and the (TI / TTOT) may decrease dramatically. Excessive work of breathing is the common cause of elevated (TI / TTOT)
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The Winning Weaning Parameters
3
http://lungs4us.tripod.com/id21.htm
21/1438042988840.31_20150728002308-00251-ip-10-236-191-2_144186532_1.json
00a95e53_The_Winning_Weaning_Parameters__3
[0] Pressure Time Index [1] .05-1.2 [2] <.15* [3]
Pressure Time Index (PTI) is a measure of strength and endurance combined into one value. It combines the strength measurement of esophageal pressure and the maximum inspiratory pressure with the endurance value of respiratory time fraction.
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The Winning Weaning Parameters
3
http://lungs4us.tripod.com/id21.htm
21/1438042988840.31_20150728002308-00251-ip-10-236-191-2_144186532_1.json
00a95e53_The_Winning_Weaning_Parameters__3
[0] Airway Resistance [1] 2-5 cmH2O/L/sec [2] <15 cmH2O/L/sec [3]
There are two kinds: Mean Airway Resistance - the result of friction in the patient airways and endotracheal tube throughout the entire respiratory cycle. Expiratory Airway Resistance is the result of friction in the patient's airways, endotracheal tube and expiratory limb of the ventilator circuit during expiration only. Airway resistance normally varies inversely with lung volume and increases in obstructive and reactive airways disease. It increases rapidly with decreases in ET tube size as a result of Poiseulle's Law.
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The Winning Weaning Parameters
3
http://lungs4us.tripod.com/id21.htm
21/1438042988840.31_20150728002308-00251-ip-10-236-191-2_144186532_1.json
00a95e53_The_Winning_Weaning_Parameters__3
[0] Lung Compliance [1] 50-100 ml/cm H2O [2] >25 ml/cm H2O [3]
Don't forget to subtract the PEEP:-) If you don't know how to calculate this parameter yet, please drop me an e-mail and include your school and your instructor.
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The Winning Weaning Parameters
3
http://lungs4us.tripod.com/id21.htm
21/1438042988840.31_20150728002308-00251-ip-10-236-191-2_144186532_1.json
00a95e53_The_Winning_Weaning_Parameters__3
[0] Pressure Time Product [1] 200-300 cm H2O/sec/min [3]
Pressure Time Product (PTP) is an estimate of metabolic work (oxygen consumption) of the respiratory muscles. This maybe used to evaluate patient effort to overcome both mechanical and isometric force of respiration. PTP decreases with the application of optimal pressure support (PSV) and continuous positive airway pressure (CPAP). PTP varies directly with total lung resistance. This variable is an important indicator of the actual patient effort to breath. Any isometric muscle contraction by the patient exerted to overcome Auto PEEP or to open the inspiratory demand system results in no tidal volume change and, therefore, accomplishes little or no measurable work. In this case, PTP may reflect the patient's muscular effort more faithfully than work of breathing. Non- intubated patients should average between 60-80 cm H2O/sec/min.
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The Winning Weaning Parameters
3
http://lungs4us.tripod.com/id21.htm
21/1438042988840.31_20150728002308-00251-ip-10-236-191-2_144186532_1.json
00a95e53_The_Winning_Weaning_Parameters__3
[0] Maximum Inspiratory Pressure [1] -30 cm H2O low effort -140 cm H2O high effort [2] >-20 cm H2O* low effort [3]
Maximum Inspiratory Pressure (MIP) is the pressure change measured by esophageal balloon, that the patient can generate when the airway is occluded for several breaths. MIP is a reflection of diaphragmatic strength and may also be used to monitor respiratory muscle endurance when serial measurements are made. MIP differs slightly from the more commonly used negative inspiratory force (NIF), which is measured at the mouth but also reflects or measures diaphragmatic strength.
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The Winning Weaning Parameters
3
http://lungs4us.tripod.com/id21.htm
21/1438042988840.31_20150728002308-00251-ip-10-236-191-2_144186532_1.json
00a95e53_The_Winning_Weaning_Parameters__3
[0] Auto PEEP [1] 0 [2] <3 cm H2O [3]
Auto PEEP results when insufficient expiratory time is available between breath to reestablish resting equilibrium. A residual alveolar pressure remains at the end exhalation which is undetected by the ventilators circuitry. Causes of Auto PEEP are: too large delivered tidal volume, too short expiratory time, increased circuit impedance, low peak inspiratory flows, high respiratory rate, expiratory airways obstruction or dynamic airways collapse.
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The Winning Weaning Parameters
3
http://lungs4us.tripod.com/id21.htm
21/1438042988840.31_20150728002308-00251-ip-10-236-191-2_144186532_1.json
00a95e53_The_Winning_Weaning_Parameters__3
[0] P0.1 Respiratory Drive [1] 2-4 cmH2O [2] <6 cmH2O [3]
P0.1 Respiratory Drive actually measures the neural drive to stimulate the force of diaphragmatic contraction. It is defined at the airway occlusion pressure at the first 100 msec after airway closure prior to the patient's conscious recognition of occlusion. A heightened Respiratory Drive increases work expenditure during patient initiated ventilator breaths and may indicate a problem in the cardiopulmonary system. It plays an essential part during machine assisted breaths in determining the energy expenditure of the patient. A low value for P0.1 Respiratory Drive may indicate when respiratory drive is blunted. Problems with P0.1 Respiratory Drive therefore, are important indicators of the ability of the patient to wean from mechanical ventilation.
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The Winning Weaning Parameters
3
http://lungs4us.tripod.com/id21.htm
21/1438042988840.31_20150728002308-00251-ip-10-236-191-2_144186532_1.json